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{07} {35} {36} Both allopurinol and the uricosuric antigout agents are effective in patients whose 24-hour renal excretion of uric acid is 800 mg (4. Allopurinol will not relieve a gout attack that has already started. This pathway of Thioguanine inactivation is not dependent on the action of xanthine oxidase, and an inhibitor of that enzyme (such as allopurinol) will not block the detoxification of Thioguanine even though the inactive 6-thioxanthine is normally further oxidized by xanthine oxidase to thiouric acid before it is eliminated. Do not use this medication if you are allergic to didanosine, or if you are also taking allopurinol (Zyloprim) or ribavirin (Rebetol, Ribasphere, Copegus Virazole). {06} {35} {36} However, the uricosuric agents are less toxic than allopurinol and should be considered for use when appropriate {37}. There is no specific information comparing use of allopurinol in the elderly with use in other age groups.
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